Factor VIII Antigen, Activity, and Mutations in Hemophilia A

Detection of Factor VIII Inhibitors in Hemophilia A Patients

Background: Factor VIII administration to hemophilia A patients results in an immune response (inhibitor formation) which significantly complicates the therapy. The present study was performed to determine the prevalence of inhibitor development in hemophilia A patients receiving recombinant factor VIII therapy. Materials and Methods: This was an observational descriptive study. Clotting fac...

Coagulation Therapy in Hemophilia A and its Relation to Factor VIII Inhibitor in Northeast of Iran

Antibodies to factor VIII. I. Variations in stability of antigen-antibody complexes in hemophilia A.

Human factor VIll-anti-factor VIII comThe extent of dissociation was measured plexes were formed in vitro in slight antiby the recovery of anti-factor VIII activity. gen excess, using plasma of hemophiliacs Increasing resistance of complexes towho were found to have antibodies neuwards dissociation was observed in the tralizing AHF activity. These complexes, plasma of the patients whose titer o...

Factor VIII products and inhibitors in severe hemophilia A.

n engl j med 368;15 nejm.org april 11, 2013 1456 improves outcomes as compared with less complete revascularization.2 However, our trial involved highly experienced interventional cardiologists and surgeons who attempted to maximize the completeness of revascularization. Substantially more complete PCI-based revascularization is therefore unlikely in other institutions. Serruys and Farooq sugge...

detection of factor viii inhibitors in hemophilia a patients

background: factor viii administration to hemophilia a patients results in an immune response (inhibitor formation) which significantly complicates the therapy. the present study was performed to determine the prevalence of inhibitor development in hemophilia a patients receiving recombinant factor viii therapy. materials and methods: this was an observational descriptive study. clotting factor...